منابع مشابه
HLA-G بررسی ساختار و عملکرد
HLA-G is a nonclassical HLA class Ib, which is located on chromosome 6 (6p.21.3). In contrast to HLA class I molecules, HLA-G has restricted polymorphism. Expression of this molecule in the physiological conditions limits to certain tissues such as thymus, cornea, nail matrix, trophoblast and pancreas. Up to now, 50 alleles of HLA-G molecules have been discovered with 16 distinct functional pro...
متن کاملHLA-G*0105N null allele encodes functional HLA-G isoforms.
Expression of the nonclassical HLA class I antigen, HLA-G, is associated with immune tolerance in view of its role in maintaining the fetus in utero, allowing tumor escape, and favoring graft acceptance. Expressed on invasive trophoblast cells, HLA-G molecules bind inhibitory receptors on maternal T lymphocytes and NK cells, thereby blocking their cytolytic activities and protecting the fetus f...
متن کاملHLA-G: A Versatile Biomarker
HLA-G is a non-classical MHC Class I molecule that is usually restricted to cytotrophoblasts and other fetal cells in order to protect the fetus from maternal immune responses. However, HLA-G is expressed during viral infections and cancer. The presence of soluble HLA-G, sHLA-G, in serum is noted in various instances of human diseases. Serum HLA-G can serve as a biomarker, which makes it a uniq...
متن کاملP-214: Parental Contribution of HLA-G*0106 and G*0105N to Repeated Implantation Failure
Background: HLA-G, as a tolerogenic molecule, expressed in cytotrophoblast cells and playing an important role in the suppression of the immune response in maternal decidua. Today Interaction of the extracellular domains of HLA-G protein with cell receptors of immune system, including CD8, LILRB1, LILRB2 and killer cell immunoglobulin-like receptor KIR2DL4, was well known. Materials and Methods...
متن کاملHLA-G and lymphoproliferative disorders.
The immunomodulatory properties of the HLA-G molecule explain its relevance in malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and variable distribution of alternatively spliced HLA-G mRNA isoforms, (ii) a rare cell surface expression in diffuse large cell lymphomas with HLA class I loss in half of cases, and (iii) an increased serum level of sHLA-G in half...
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ژورنال
عنوان ژورنال: Nova
سال: 2006
ISSN: 2462-9448,1794-2470
DOI: 10.22490/24629448.352